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By Bert W. O’Malley, William T. Schrader, Ming-Jer Tsai (auth.), George P. Chrousos, D. Lynn Loriaux, Mortimer B. Lipsett (eds.)

This quantity represents the 1st try to found in one position the scientific syndromes and the pathophysiologic foundation for the "resistance states" to every of the periods of steroid hormones. Glucocorticoids, mineralocorticoids, androgens, estrogens, progesterone and nutrition D have commonly various roles starting from the keep an eye on of homeostasis to replica and bone formation. they're comparable in that they proportion a chemical constitution and that their motion is within the mobile nucleus the place they set off transcription of particular genes resulting in synthesis of function-specific proteins. scientific syndromes of steroid hormone resistance to androgens (complete and partial testicular feminization), aldosterone (pseudo­ hypoaldosteronism) and diet D (vitamin D-dependent rickets kind II) were recognized for a few years. Progesterone and glucocorticoid resistance syndromes were defined only in the near past. Resistance to estrogens has now not been said in guy or in animals. it really is was hoping targeted reexamination of what's identified approximately each one of those stipulations on the medical and molecular degrees will improve our figuring out of the functionality of those hormones and their mechanisms of motion. New perception and examine tasks may still end result. G.P. Chrousos D.L. Loriaus M.B. Lipsett vii ACKNOWLEDGMENTS The contents of this quantity are dependent partially at the court cases of a global convention held in Bethesda in the summertime of 1984. This convention was once backed by means of the nationwide Institute of kid health and wellbeing and Human improvement, Bethesda, Maryland.

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