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By McFadden G., Moyer R.

Greater than part a dozen poxvirus-encoded participants of the serpin superfamily of serine proteinase inhibitors were chanced on, yet just one of those, SERP-1 of myxoma virus, features as an extracellular immunomodulator. SERP-1 is expressed as a secreted glycoprotein that protects myxoma-infected cells from clearance by way of macrophages and different inflammatory cells. Biochemically, SERP-1 protein binds and inhibits a spectrum of serine proteinases, resembling plasmin, urokinase and tissue plasminogen activator, yet its designated mode of motion in virus-infected lesions is still elucidated. The purified SERP-1 protein by myself capabilities as a effective antiinflammatory reagent in a number of animal versions of irritation.

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