By Tie-Hua Ng
Take Your NI Trial to the subsequent Level
Reflecting the great learn on noninferiority (NI) designs from the prior 15 years, Noninferiority trying out in medical Trials: matters and Challenges explains find out how to decide on the NI margin as a small fraction of the healing impression of the energetic keep watch over in a medical trial. Requiring no previous wisdom of NI trying out, the e-book is well available to either statisticians and nonstatisticians excited about drug development.
With over twenty years of expertise during this region, the writer introduces the fundamental parts of the NI trials separately in a logical order. He discusses matters with estimating the influence dimension in response to historic placebo keep an eye on trials of the lively keep watch over. The e-book covers primary techniques concerning NI trials, resembling assay sensitivity, fidelity assumption, discounting, and renovation. It additionally describes sufferer populations, three-arm trials, and the equivalence of 3 or extra groups.
Read or Download Noninferiority Testing in Clinical Trials: Issues and Challenges (Chapman & Hall/CRC Biostatistics Series) PDF
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