By Bannwarth W., Hinzen B.
"This progressive procedure allows natural and medicinal chemists to synthesize millions or perhaps thousands of probably fascinating compounds in one response series. mixed with present equipment of excessive throughput research, combinatorial equipment have nearly thoroughly changed the conventional step by step synthesis of strength drugs." "Retaining its practice-oriented procedure, this new version has been completely up to date to mirror advancements in parallel synthesis, whereas a brand new bankruptcy on screening enhances the review of combinatorial approach and artificial tools. the result's a instruction manual adapted to the wishes of the undefined, with just about all the authors affiliated with best pharmaceutical companies."--BOOK JACKET. learn more... content material: Purification rules in high-speed solution-phase synthesis / Steffen Weinbrenner, C. Christoph Tzschucke -- Linkers for solid-phase natural synthesis (SPOS) and combinatorial techniques on strong helps / Willi Bannwarth -- Cyclative cleavage : a flexible notion in solid-phase natural chemistry / Josef Pernerstorfer -- C-C bond-forming reactions / Wolfgang K.-D. Brill, Gianluca Papeo -- Combinatorial synthesis of heterocycles / Eduard R. Felder, Andreas L. Marzinzik -- Polymer-supported reagents : practise and use in parallel natural synthesis / Berthold Hinzen, Michael G. Hahn -- Encoding ideas for combinatorial libraries / Berthold Hinzen -- Automation and units for combinatorial chemistry and parallel natural synthesis / Christian Zechel -- Computer-assisted library layout / Andreas Dominik -- Assays for high-throughput screening in drug discovery / Christian M. Apfel, Thilo Enderle. summary: Combinatorial chemistry is a innovative technique, which lets you synthesize thousands of compounds inside of a couple of steps and in a really brief period of time. hundreds of thousands of goods, e.g. capability medicinal drugs, could be analyzed in a single move, so you recognize very quick if one or a couple of elements on your product blend express organic task. learn more...
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